武藤 昌図 教授

[研究指導課程]
博士前期課程

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博士（医学）

研究室ページ

専門・研究分野

医療科学、生理学、薬理学

がん治療薬探索、細胞培養、新規評価法、細胞産生物質

1997年以降の主要論文を示します。

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institutes anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.
O'Connor, PM., Jackman, B., Bae, I., Myers, TG., Fan, S., Mutoh, M., Scudiero, DA., Monks, A.,
Weinstein, JN., Friend, S., Fornance Jr, A., and Kohn, KW.
Cancer Res. 57, 4285-4300 (1997)

Reversal of heavy metal resistance in multidrug-resistant human KB carcinoma cells.
Chen, ZS., Mutoh, M., Sumizawa, T., Furukawa, T., Haraguchi, M., Tani, A., Akiyama, S.
Biochem. Biophys. Res. Commun. 236, 586-590 (1997)

An active efflux system for heavy metals in cisplatin-resistant human KB Carcinoma cells.
Chen, ZS, Mutoh, M., Sumizawa, T., Furukawa, T., Haraguchi, M., Tani, A., Saijo, N., Kondo, T. and Akiyama, S.
Experimental Cell Research 240, 312-320 (1998)

Functional site studies with peptide segments of Cdk inhibitory proteins.
Roller, PP., Lung, FT., Mutoh, M. and O’Connor, PM
In Peptide: Tam, JP. And Kauyama, PTP. (Eds.); Kluwer Academic Publishers;547-548 (1999)
A p21(Waf1/Cip1) carboxy-terminal peptide exhibited cyclin-dependent kinase-inhibitory activity and cytotoxicity when introduced into human cells.
Mutoh, M., Lung, FT., Long, YQ., Roller, PP., Sikorski, RS. and O’Connor, PM.
Cancer Res. 59, 3480-3488 (1999)

Copper-transporting P-type adenosine triphosphate (ATP7B) is associated with cisplatin-resistance.
Komatsu, M., Sumizawa, T., Mutoh, M., Chen, ZS., Terada, K., Furukawa, T., Yang, XL., Gao, H., Miura, N., Sugiyama, T. and Akiyama, S.
Cancer Res. 60, 1312-1316 (2000)

Expression of multidrug resistance-related transporters in human breast carcinoma.
Kanzaki, A., Toi, M., Nakayama, K., Bando, H., Mutoh, M., Uchida, T., Fukumoto, M. and Takebayashi, Y.
Jpn. J. Cancer Res. 92, 452-458 (2001)

Expression of multidrug resistance associated transporters (MDR1, MRP1, LRP and BCRP) in porcine oocyte.
Takabayashi, Y., Nakayama, K., Fujioka, T., Kanzaki, A., Mutoh, M., Uchida, T., Miyazaki, K., Ito, M. and Fukumoto, M.
Int. J. Mol. Med. 7, 397-400 (2001)

Loss of heterozygosity of nucleotide excision repair factors in sporadic ovarian, colon and lung carcinomas: implication for their roles of carcinogenesis in human solid tumors.
Takebayashi, Y., Nakayama, K., Kanzaki, A., Miyashita, H., Ogura, O., Mori, S., Mutoh, M., Miyazaki, K., Fukumoto, M. and Pommier, Y.
Cancer Lett. 174, 115-125 (2001)

Copper-transporting P-type adenosine triphosphate (ATP7B) is expressed in human breast carcinoma.
Kanzaki, A., Toi, M., Neamati, N., Miyashita, H., Oubu, M., Nakayama, K., Bando, H., Ogawa, K., Mutoh, M., Mori, S., Terada, K., Sugiyama, T., Fukumoto, M. and Takebayashi, Y.
Jpn. J. Cancer Res. 93, 70-77 (2002)

Expression of the anti-apoptotic gene survivn in myelodysplastic syndrome.
Badran, A., Yoshida, A., Wano, Y., Mutoh, M., Imamura, S., Yamashita, T., Tsutani, T., Inuzaka, M. and Ueda, T.
Int. J. Oncol. 22, 59-64 (2003)

Mutation analysis of copper-transporting P-type adenosine triphosphatase (ATP7B) in human solid carcinomas.
Kanzaki, A., Nakayama, K., Miyashita, H., Shirata, S., Nitta, Y., Oubu, M., Higashimoto M., Mutoh, M., Mori, S., Konno, S., Ogawa, K., Toi, M. and Takebayashi, Y.
Anticancer Res. 23(2C), 1913-1915 (2003)

Purification, molecular cloning, and expression of a novel growth promotive factor for retinal pigment epithelial cells, REF-1/TFPI-2.
Tanaka, Y., Utsumi, J., Matsui, M., Sudo, T., Nakamura, N., Mutoh, M., Kajita, A.,Sone, S., Kigasawa, K., Shibuya, M., Reddy, VN., Zhang, Q. and Iwata, T.
Invest. Ophthalmol. Vis. Sci. 45, 245-252 (2004)

Prognostic value of the Cu-transporting ATPase in ovarian carcinoma patients receiving cisplatin-based chemotherapy.
Nakayama, K., Kanzaki, A., Terada, K., Mutoh, M., Ogawa, K., Sugiyama, T., Takenoshita, S., Itoh, K., Yaegashi, N., Miyazaki, K., Neamati, N. and Takebayashi, Y.
Clin. Cancer Res. 10, 2804-2811 (2004)

Overexpression of survivin in primary ATL cells and Sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines.
Che, X.-F., Zheng, C.-L., Owatari, S., Mutoh, M., Gotanda, T., Jeung, H.-C.,　Furukawa, T., Ikeda, R., Haraguchi, M., Arima, N., Tanaka, Y. and Akiyama, S.
Blood 15, 4880-4887 (2006)